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Rahman MH, Kim CS, Lee KJ. Molecular hydrogen gas and its therapeutic potential in recent disease progression. Med Gas Res. 2025 Mar 1;15(1):120-121. doi: 10.4103/mgr.MEDGASRES-D-24 00012. Epub 2024 Sep 25. PMID: 39436178; PMCID: PMC11515071.
Yang F, Ghosh A, Katwala S and Chu X-P (2024) Commentary: Intraganglionic reactive oxygen species mediate inflammatory pain and hyperalgesia through TRPA1 in the rat. Front. Pain Res. 5:1456548. doi: 10.3389/fpain.2024.1456548
Zhou SZ, Zhou YL, Ji F, Li HL, Lv H, Zhang Y, Xu H. Analgesic Effect of Methane Rich Saline in a Rat Model of Chronic Inflammatory Pain. Neurochem Res. 2018 Apr;43(4):869-877. doi: 10.1007/s11064-018-2490-2. Epub 2018 Feb 6. PMID: 29411262.
Haddad JJ. On the enigma of pain and hyperalgesia: A molecular perspective. Biochem Biophys Res Commun. 2007 Feb 9;353(2):217-24. doi: 10.1016/j.bbrc.2006.12.032. Epub 2006 Dec 12. PMID: 17184730.
McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp Neurol. 2005 Apr;192(2):444-62. doi: 10.1016/j.expneurol.2004.11.001. PMID: 15755561.
Hsueh SF, Lu CY, Chao CS, Tan PH, Huang YW, Hsieh SW, Hsiao HT, Chung NC, Lin SH, Huang PL, Lyu PC, Yang LC. Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation. Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):113-9. doi: 10.1016/j.molbrainres.2004.03.016. PMID: 15193428.
Liu X, Gong R, Peng L, Zhao J. Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1. Mol Pain. 2023 Jan-Dec;19:17448069231158290. doi: 10.1177/17448069231158290. PMID: 36733260; PMCID: PMC9926008.
Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain. 2005 Nov;118(1-2):70-9. doi: 10.1016/j.pain.2005.07.016. Epub 2005 Oct 5. PMID: 16213085.
Stegmann JU, Muth-Selbach U, Holthusen H. Die Bedeutung von Stickstoffmonoxid (NO) für Nozizeption und spinale Schmerzverarbeitung [The significance of nitric oxide in nociception and spinal pain processing]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 May;36(5):276-81. German. doi: 10.1055/s-2001-14474. PMID: 11413696.
Dai S, Ji J, Li R, Gao L, He X. Stellate Ganglion Block Attenuates LPS-Induced Acute Lung Injury by Activating Sirt3 Regulation of Oxidative Stress and Inflammation. Biomedicines. 2024 May 22;12(6):1148. doi:10.3390/biomedicines12061148. PMID: 38927355; PMCID: PMC11200983.
Liu Y, Shen T, Li Q, Yu X, Liu Y, Zhou C, Han J, Zhu Y. Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives. Med Gas Res. 2025 Dec 1;15(4):488 495. doi: 10.4103/mgr.MEDGASRES-D-24-00161. Epub 2025 Apr 29. PMID: 40300884; PMCID: PMC12124698.
Yao K, Dou B, Zhang Y, Chen Z, Li Y, Fan Z, Ma Y, Du S, Wang J, Xu Z, Liu Y, Lin X, Wang S, Guo Y. Inflammation-the role of TRPA1 channel. Front Physiol. 2023 Feb 16;14:1093925. doi: 10.3389/fphys.2023.1093925. PMID: 36875034; PMCID: PMC9977828.
Li J, Dong D, Sun Y, Wang Q, Li Y, Tao X, Wang K, Zhao L. Astaxanthin alleviates spinal nerve ligation-induced neuropathic pain by modulating propionic acid levels. Phytomedicine. 2025 Apr;139:156448. doi: 10.1016/j.phymed.2025.156448. Epub 2025 Feb 4. PMID: 39951970.
Jeyaraman N, Jeyaraman M, Ramasubramanian S, Murugan S, Nallakumarasamy A, Muthu S. Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis. World J Orthop. 2026 Jan 18;17(1):111911. doi: 10.5312/wjo.v17.i1.111911. PMID: 41608485; PMCID: PMC12836127.
Chen W, Zhang HT, Qin SC. Neuroprotective Effects of Molecular Hydrogen: A Critical Review. Neurosci Bull. 2021 Mar;37(3):389-404. doi: 10.1007/s12264-020-00597-1. Epub 2020 Oct 20. PMID: 33078374; PMCID: PMC7954968.
Cai L, Ru B, Ren H, Cai F, Zeng L, Yang J, Wang S, Zhang H, Li Y, Zhang L. Gas therapy: an innovative application for intervertebral disc degeneration. Med Gas Res. 2026 Sep 1;16(3):293-302. doi: 10.4103/mgr.MEDGASRES-D-25-00191. Epub 2026 Jan 6. PMID: 41496306.
Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, Wang G. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015 Oct;38(5):1835-46. doi:10.1007/s10753-015-0161-x. PMID: 25820467.
Silverman HA, Chen A, Kravatz NL, Chavan SS and Chang EH (2020) Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation. Front. Immunol. 11:590261. doi: 10.3389/fimmu.2020.590261
Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L, Ghelardini C, Supuran CT, Carta F. Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem. 2019 Aug 8;62(15):7233-7249. doi: 10.1021/acs.jmedchem.9b00845. Epub 2019 Jul 23. PMID: 31287314.
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients. J Pers Med. 2022 Dec 28;13(1):67. doi: 10.3390/jpm13010067. PMID: 36675728; PMCID: PMC9867387.
Chen Y, Lei K, Li Y, Mu Z, Chu T, Hu J, Zeng B, Wang Y, Shen J, Cai X, Shi T, Deng H. Synergistic effects of NO/H2S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform. Acta Biomater. 2025 Mar 1;194:288-304. doi: 10.1016/j.actbio.2025.01.013. Epub 2025 Jan 10. PMID: 39798637.
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients. J Pers Med. 2022 Dec 28;13(1):67. doi: 10.3390/jpm13010067. PMID: 36675728; PMCID: PMC9867387.
Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013 Nov;40(6):857-63. doi: 10.1017/s0317167100016024. PMID: 24257230.
Sarkar S, Kumar R, Matson JB. Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide. Macromol Biosci. 2024 Jan;24(1):e2300138. doi: 10.1002/mabi.202300138. Epub 2023 Jul 12. PMID: 37326828; PMCID: PMC11180494.
Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, Wang G. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015 Oct;38(5):1835-46. doi: 10.1007/s10753-015-0161-x. PMID: 25820467.
Wu Y, Yuan M, Song J, Chen X, Yang H. Hydrogen Gas from Inflammation Treatment to Cancer Therapy. ACS Nano. 2019 Aug 27;13(8):8505-8511. doi: 10.1021/acsnano.9b05124. Epub 2019 Jul 22. PMID: 31329427.
Chawla LS. Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness. Intensive Care Med Exp. 2025 Sep 12;13(1):94. doi: 10.1186/s40635-025-00798-w. PMID: 40938520; PMCID: PMC12431974.
Mouzakis FL, Hima F, Kashefi A, Greven J, Rink L, van der Vorst EPC, Jankowski J, Mottaghy K, Spillner J. Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study. Biomedicines. 2024 Aug 18;12(8):1883. doi: 10.3390/biomedicines12081883. PMID: 39200347; PMCID: PMC11351264.
Chen Y, Lei K, Li Y, Mu Z, Chu T, Hu J, Zeng B, Wang Y, Shen J, Cai X, Shi T, Deng H. Synergistic effects of NO/H2S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform. Acta Biomater. 2025 Mar 1;194:288-304. doi: 10.1016/j.actbio.2025.01.013. Epub 2025 Jan 10. PMID: 39798637.
Hong Y, Sun LI, Sun R, Chen H, Yu Y, Xie K. Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. Exp Ther Med. 2016 Jun;11(6):2590-2596. doi: 10.3892/etm.2016.3231. Epub 2016 Apr 6. PMID: 27284352; PMCID: PMC4887775.
Jin Y, Liu S, Wang X, Wang C, Ruan Q, Li W. Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide-Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy. Adv Mater. 2025 Feb;37(5):e2413108. doi: 10.1002/adma.202413108. Epub 2024 Dec 6. PMID: 39641190.
Ye S, Jin N, Liu N, Cheng F, Hu L, Zhang G, Li Q, Jing J. Gases and gas-releasing materials for the treatment of chronic diabetic wounds. Biomater Sci. 2024 Jun 25;12(13):3273-3292. doi: 10.1039/d4bm00351a. PMID: 38727636.
Ho, W.-T.; Yu, T.-H.; Chao, W.-H.; Wang, B.-Y.; Kuo, Y.-Y.; Lin, M.-H.; Yeh, S.H.-H. Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch. Appl. Sci. 2021, 11, 11680. https://doi.org/10.3390/app112411680
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Rahman MH, Kim CS, Lee KJ. Molecular hydrogen gas and its therapeutic potential in recent disease progression. Med Gas Res. 2025 Mar 1;15(1):120-121. doi: 10.4103/mgr.MEDGASRES-D-24 00012. Epub 2024 Sep 25. PMID: 39436178; PMCID: PMC11515071.
Yang F, Ghosh A, Katwala S and Chu X-P (2024) Commentary: Intraganglionic reactive oxygen species mediate inflammatory pain and hyperalgesia through TRPA1 in the rat. Front. Pain Res. 5:1456548. doi: 10.3389/fpain.2024.1456548
Zhou SZ, Zhou YL, Ji F, Li HL, Lv H, Zhang Y, Xu H. Analgesic Effect of Methane Rich Saline in a Rat Model of Chronic Inflammatory Pain. Neurochem Res. 2018 Apr;43(4):869-877. doi: 10.1007/s11064-018-2490-2. Epub 2018 Feb 6. PMID: 29411262.
Haddad JJ. On the enigma of pain and hyperalgesia: A molecular perspective. Biochem Biophys Res Commun. 2007 Feb 9;353(2):217-24. doi: 10.1016/j.bbrc.2006.12.032. Epub 2006 Dec 12. PMID: 17184730.
McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp Neurol. 2005 Apr;192(2):444-62. doi: 10.1016/j.expneurol.2004.11.001. PMID: 15755561.
Hsueh SF, Lu CY, Chao CS, Tan PH, Huang YW, Hsieh SW, Hsiao HT, Chung NC, Lin SH, Huang PL, Lyu PC, Yang LC. Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation. Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):113-9. doi: 10.1016/j.molbrainres.2004.03.016. PMID: 15193428.
Liu X, Gong R, Peng L, Zhao J. Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1. Mol Pain. 2023 Jan-Dec;19:17448069231158290. doi: 10.1177/17448069231158290. PMID: 36733260; PMCID: PMC9926008.
Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain. 2005 Nov;118(1-2):70-9. doi: 10.1016/j.pain.2005.07.016. Epub 2005 Oct 5. PMID: 16213085.
Stegmann JU, Muth-Selbach U, Holthusen H. Die Bedeutung von Stickstoffmonoxid (NO) für Nozizeption und spinale Schmerzverarbeitung [The significance of nitric oxide in nociception and spinal pain processing]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2001 May;36(5):276-81. German. doi: 10.1055/s-2001-14474. PMID: 11413696.
Dai S, Ji J, Li R, Gao L, He X. Stellate Ganglion Block Attenuates LPS-Induced Acute Lung Injury by Activating Sirt3 Regulation of Oxidative Stress and Inflammation. Biomedicines. 2024 May 22;12(6):1148. doi:10.3390/biomedicines12061148. PMID: 38927355; PMCID: PMC11200983.
Liu Y, Shen T, Li Q, Yu X, Liu Y, Zhou C, Han J, Zhu Y. Various gases for the treatment of neuropathic pain: mechanisms, current status, and future perspectives. Med Gas Res. 2025 Dec 1;15(4):488 495. doi: 10.4103/mgr.MEDGASRES-D-24-00161. Epub 2025 Apr 29. PMID: 40300884; PMCID: PMC12124698.
Yao K, Dou B, Zhang Y, Chen Z, Li Y, Fan Z, Ma Y, Du S, Wang J, Xu Z, Liu Y, Lin X, Wang S, Guo Y. Inflammation-the role of TRPA1 channel. Front Physiol. 2023 Feb 16;14:1093925. doi: 10.3389/fphys.2023.1093925. PMID: 36875034; PMCID: PMC9977828.
Li J, Dong D, Sun Y, Wang Q, Li Y, Tao X, Wang K, Zhao L. Astaxanthin alleviates spinal nerve ligation-induced neuropathic pain by modulating propionic acid levels. Phytomedicine. 2025 Apr;139:156448. doi: 10.1016/j.phymed.2025.156448. Epub 2025 Feb 4. PMID: 39951970.
Jeyaraman N, Jeyaraman M, Ramasubramanian S, Murugan S, Nallakumarasamy A, Muthu S. Molecular hydrogen therapy in musculoskeletal conditions: An evidence-based review and critical analysis. World J Orthop. 2026 Jan 18;17(1):111911. doi: 10.5312/wjo.v17.i1.111911. PMID: 41608485; PMCID: PMC12836127.
Chen W, Zhang HT, Qin SC. Neuroprotective Effects of Molecular Hydrogen: A Critical Review. Neurosci Bull. 2021 Mar;37(3):389-404. doi: 10.1007/s12264-020-00597-1. Epub 2020 Oct 20. PMID: 33078374; PMCID: PMC7954968.
Cai L, Ru B, Ren H, Cai F, Zeng L, Yang J, Wang S, Zhang H, Li Y, Zhang L. Gas therapy: an innovative application for intervertebral disc degeneration. Med Gas Res. 2026 Sep 1;16(3):293-302. doi: 10.4103/mgr.MEDGASRES-D-25-00191. Epub 2026 Jan 6. PMID: 41496306.
Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, Wang G. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015 Oct;38(5):1835-46. doi:10.1007/s10753-015-0161-x. PMID: 25820467.
Silverman HA, Chen A, Kravatz NL, Chavan SS and Chang EH (2020) Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation. Front. Immunol. 11:590261. doi: 10.3389/fimmu.2020.590261
Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L, Ghelardini C, Supuran CT, Carta F. Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem. 2019 Aug 8;62(15):7233-7249. doi: 10.1021/acs.jmedchem.9b00845. Epub 2019 Jul 23. PMID: 31287314.
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients. J Pers Med. 2022 Dec 28;13(1):67. doi: 10.3390/jpm13010067. PMID: 36675728; PMCID: PMC9867387.
Chen Y, Lei K, Li Y, Mu Z, Chu T, Hu J, Zeng B, Wang Y, Shen J, Cai X, Shi T, Deng H. Synergistic effects of NO/H2S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform. Acta Biomater. 2025 Mar 1;194:288-304. doi: 10.1016/j.actbio.2025.01.013. Epub 2025 Jan 10. PMID: 39798637.
Lin H, Du J, Tian Z, Yu Y, Cui Y, Xie K. Hydrogen Gas Treatment Improves Postoperative Delirium and Cognitive Dysfunction in Elderly Noncardiac Patients. J Pers Med. 2022 Dec 28;13(1):67. doi: 10.3390/jpm13010067. PMID: 36675728; PMCID: PMC9867387.
Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress. Can J Neurol Sci. 2013 Nov;40(6):857-63. doi: 10.1017/s0317167100016024. PMID: 24257230.
Chen Y, Chen H, Xie K, Liu L, Li Y, Yu Y, Wang G. H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation. 2015 Oct;38(5):1835-46. doi: 10.1007/s10753-015-0161-x. PMID: 25820467.
Wu Y, Yuan M, Song J, Chen X, Yang H. Hydrogen Gas from Inflammation Treatment to Cancer Therapy. ACS Nano. 2019 Aug 27;13(8):8505-8511. doi: 10.1021/acsnano.9b05124. Epub 2019 Jul 22. PMID: 31329427.
Chawla LS. Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness. Intensive Care Med Exp. 2025 Sep 12;13(1):94. doi: 10.1186/s40635-025-00798-w. PMID: 40938520; PMCID: PMC12431974.
Mouzakis FL, Hima F, Kashefi A, Greven J, Rink L, van der Vorst EPC, Jankowski J, Mottaghy K, Spillner J. Molecular Hydrogen and Extracorporeal Gas Exchange: A Match Made in Heaven? An In Vitro Pilot Study. Biomedicines. 2024 Aug 18;12(8):1883. doi: 10.3390/biomedicines12081883. PMID: 39200347; PMCID: PMC11351264.
Chen Y, Lei K, Li Y, Mu Z, Chu T, Hu J, Zeng B, Wang Y, Shen J, Cai X, Shi T, Deng H. Synergistic effects of NO/H2S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform. Acta Biomater. 2025 Mar 1;194:288-304. doi: 10.1016/j.actbio.2025.01.013. Epub 2025 Jan 10. PMID: 39798637.
Hong Y, Sun LI, Sun R, Chen H, Yu Y, Xie K. Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. Exp Ther Med. 2016 Jun;11(6):2590-2596. doi: 10.3892/etm.2016.3231. Epub 2016 Apr 6. PMID: 27284352; PMCID: PMC4887775.
Jin Y, Liu S, Wang X, Wang C, Ruan Q, Li W. Multifunctional Microneedle Patches Loaded With Engineered Nitric Oxide-Releasing Nanocarriers for Targeted and Synergistic Chronic Wound Therapy. Adv Mater. 2025 Feb;37(5):e2413108. doi: 10.1002/adma.202413108. Epub 2024 Dec 6. PMID: 39641190.
Ye S, Jin N, Liu N, Cheng F, Hu L, Zhang G, Li Q, Jing J. Gases and gas-releasing materials for the treatment of chronic diabetic wounds. Biomater Sci. 2024 Jun 25;12(13):3273-3292. doi: 10.1039/d4bm00351a. PMID: 38727636.
Ho, W.-T.; Yu, T.-H.; Chao, W.-H.; Wang, B.-Y.; Kuo, Y.-Y.; Lin, M.-H.; Yeh, S.H.-H. Design and In Vivo Evaluation of a Novel Transdermal Hydrogen/Oxygen-Generating Patch. Appl. Sci. 2021, 11, 11680. https://doi.org/10.3390/app112411680
