The Role of Nitrite Gas in Angiogenesis and Cellular Repair

Nitrite (NO2-) gas-releasing agents have been shown to convert into nitric oxide (NO), which subsequently participates in angiogenesis and cellular repair mechanisms. Under hypoxic conditions, the conversion efficiency of NO2- increases, aiding in the alleviation of localized ischemia. Research indicates that nitrite gas therapy can enhance regenerative capacity following myocardial ischemia and promote the migration and targeted differentiation of bone marrow-derived stem cells. Through the controlled release of nitrite via gases or nanocarriers, this approach holds significant potential for future regenerative strategies targeting chronic injuries and degenerative diseases.