Exploring the Potential of Methane (CH4) in Antioxidative and Cytoprotective Applications

Methane (CH4), a common gas primarily associated with the energy sector, has recently been identified in research for its potential antioxidative and anti-inflammatory effects. Experimental animal models have shown that inhaling low-concentration methane can mitigate ischemia-reperfusion injury in the liver and lungs, thereby promoting tissue repair. The underlying mechanisms may involve the modulation of intracellular signaling pathways, scavenging of free radicals, and balancing of immune responses. Characterized by its low toxicity and high diffusivity, methane holds promise as a component of future gaseous therapies, particularly for tissue damage associated with oxidative stress.